3 edition of Mitochondrial biogenesis and genetics found in the catalog.
Includes biliographical references and indexes.
|Statement||edited by Giuseppe M. Attardi, Anne Chomyn.|
|Series||Methods in enzymology -- v. 260, 264|
|Contributions||Attardi, Giuseppe., Chomyn, Anne.|
|The Physical Object|
Forward genetics in Arabidopsis has identified mitochondrial involvement in mutations with notable impacts on plant metabolism, growth and development. Here we consider the evidence for components involved in mitochondria biogenesis, metabolism and signalling to the by: Mitochondrial homeostasis depends on effective biogenesis, quality control mechanisms, and appropriate distribution of the mitochondrial network and is key to cell survival. Dysfunctional mitochondria can trigger apoptotic cell death and play an important role in the pathogenesis of several diseases (Nunnari and Suomalainen, ).Cited by:
The book is divided into five sections, covering mitochondrial structure and function, the role of mitochondrial DNA mutations in disease, the involvement of nuclear genes in mitochondrial disease, the role of mitochondria in neurodegeneration and ageing, and current directions and future prospects for research in this : Fiona M. Menzies. Not necessarily. There’s good evidence that individual mitochondria can fuse and exchange genetic material with one another, meaning that not all of the DNA copies in a mitochondrion are necessarily identical 1 ^1 1 start superscript, 1, end plants, chloroplast fusion appears less common, so individual chloroplasts may tend to be genetically homogeneous .
Mitochondrial biogenesis within muscle consists of two possible mutually inclusive alterations: an increase in mitochondrial content per gram of tissue and/or a change in mitochondrial composition, with an alteration in mitochondrial protein-to-lipid ratio (4). Although this phenomenon resulting from exercise has long been established, many of Author: Arsalan Damirchi, Parvin Babaei, Meysam Gholamali, Kamal Ranjbar. Abstract. The induction of mitochondrial biogenesis could potentially alleviate mitochondrial and muscle disease. We show here that dimethyl fumarate (DMF) dose-dependently induces mitochondrial biogenesis and function dosed to cells in vitro, and also dosed in vivo to mice and humans. The induction of mitochondrial gene expression is more Cited by:
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Mitochondrial Biogenesis and Genetics, Part B, Volume (Methods in Enzymology) 1st Edition Buy used On clicking this link, a new layer will be open $ On clicking this link, a new layer will be open Buy new On clicking this link, a new layer will be open $ On clicking this link, a new layer will be open.
Buy Mitochondrial Biogenesis and Genetics, Part A (Methods in Enzymology, Vol. ) (Volume ) on FREE SHIPPING on qualified orders. Purchase Mitochondrial Biogenesis and Genetics, Part B, Volume - 1st Edition. Print Book & E-Book. ISBNPurchase Mitochondrial Biogenesis and Genetics, Part A, Volume - 1st Edition.
Print Book & E-Book. ISBNselect article  Genetics and transformation of mitochondria in the green alga Chlamydomonas.
select article  Measurement of electrical potential, pH, and free calcium ion concentration in mitochondria of living cells by laser scanning confocal microscopy. Mitochondrial biogenesis and genetics. [Giuseppe Attardi; Anne Chomyn;] mitochondrial gene expression; mitochondrial genetics and gene manipulation; and mitochondrial diseases and aging.
Rating: (not yet rated) 0 with reviews - Be the first. Subjects: Book\/a>, schema:CreativeWork\/a>. The concept of mitochondrial diseases dates back only as far as the s, and they were given little credence until mutations in mitochondrial DNA were found in the late s. This international, edited book summarises the advances in human mitochondrial genetics made over the past decade and a half.
The mitochondrial genome is vital for Caenorhabditis elegans metabolism, physiology, and development. The C. elegans mitochondrial DNA is typical of animal mitochondrial genomes in its size and gene content. It is 13, nucleotides in length and encodes 36 genes: 2 ribosomal RNAs, 22 transfer RNAs.
genetics of the mitochondrial genome still offer much to be explored. Mitochondrial DNA inheritance It is generally believed that animal mtDNA is inherited exclusively from the mother. However, it was recently shown in a patient with mitochondrial myopathy that the pathogenic mtDNA was of paternal origin (Schwartz and Vissing, ).File Size: 1MB.
This international, edited book summarises the advances in human mitochondrial genetics made over the past decade and a half. During that time, numerous mutations of mitochondrial DNA have been discovered and more recently mitochondrial diseases have been linked to a number of nuclear gene : $ Mitochondrial biogenesis and genetics.
San Diego: Academic Press, © (OCoLC) Material Type: Internet resource: Document Type: Book, Internet Resource: All Authors / Contributors: Giuseppe Attardi; Anne Chomyn.
Mitochondrial Biogenesis in Health and Disease. Molecular and Therapeutic Approaches Article Literature Review (PDF Available) in Current Pharmaceutical Design. Mitochondrial Biogenesis and Genetics, Part A: (Methods in Enzymology, volume ) by Giuseppe M. Attardi and Anne Chomyn and a great selection of related books, art and collectibles available now at Gene regulatory factors encoded by the nuclear genome are essential for mitochondrial biogenesis and function.
Some of these factors act exclusively within the mitochondria to regulate the control of mitochondrial transcription, translation and other by: It also highlights the importance of the mitochondrial assembly factors and how mutations to these can lead to mitochondrial disease.
The reader is then introduced to how mtDNA is transmitted through the oocyte and how stem cells can be used to study mitochondrial biogenesis and mtDNA replication and transcription in undifferentiated Brand: Humana Press. Correct mitochondrial biogenesis requires the co-ordinated synthesis and import of approx.
– proteins encoded by the nuclear genome and synthesized on cytosolic ribosomes. mtDNA replication, as well as mitochondrial fusion and fission, which are discussed elsewhere in this volume, must also be co-ordinated.
Mitochondrial biogenesis is influenced by Cited by: The book begins with a general introduction to mitochondria, followed by laboratory methods to study the structure and function of the organelle, regulation of replication and biogenesis, and the mechanisms and functional consequences of mitophagia and mitochondrial dynamics.
Perturbations in mitochondrial function and homeostasis are pervasive in lysosomal storage diseases, but the underlying mechanisms remain unknown. Here, we report a transcriptional program that represses mitochondrial biogenesis and function in lysosomal storage diseases Niemann-Pick type C (NPC) and acid sphingomyelinase deficiency (ASM), in Author: King Faisal Yambire, Lorena Fernandez-Mosquera, Robert Steinfeld, Christiane Muehle, Elina Ikonen, I.
Abstract. This chapter is a continuation of our previous articles in this series (Bauerfeind et al. ; Riemen et al. Research activities and progress in the field of mitochondrial genetics, mitochondrial biogenesis and nuclear-mitochondrial interactions refer to the complete sequence of new mitochondrial genomes, transcription of mitochondrial DNA, Cited by: 1.
Mitochondrial biogenesis is the process by which cells increase mitochondrial mass. It was first described by John Holloszy in the s, when it was discovered that physical endurance training induced higher mitochondrial content levels, leading to greater glucose uptake by muscles.Mitochondria: Practical Protocols offers a broad collection of methods for studying the molecular biology, function, and features of mitochondria.
In the past decade, mitochondrial research has elucidated the important influence of mitochondrial processes on integral cell processes such as apoptosis and cellular aging. Mitochondrial Biogenesis and Function in Arabidopsis 11 of 33 1 is able to restore growth on non-fermentable carbon sources when expressed in a yeast cox19 n ull mutant.